Abstract

Background: To date, there is little evidence in the literature about the effects of synthetic cannabinoids “spice” and antidepressants on the mammalian immune system. Aims and Objectives: The study of the formation of immunoglobulin (Ig)G and IgM class antibodies to synthetic cannabinoids “spice” and antidepressants for a comparative assessment of the role of the class of antibodies in the detection of dependence on psychotropic drugs.
Materials and Methods: Conjugates were obtained with four antidepressants: Faverin, carbamazepine, sertraline, and fluoxetine and two synthetic cannabinoids of the “spice” type – AB-FUBINACA and ADB-CHMINACA in conjunction with the carrier protein-bovine serum albumin. The serological activity of synthesized conjugates based on the protein matrix was determined.
Results: Data were obtained on the determination of antibodies to the studied synthetic cannabinoids and antidepressants by enzyme-linked immunosorbent assay, and the immunoreactivity of mouse antibodies against heterologous haptens was established. Conclusion: The article examines in detail the issues related to the comparative analysis of the formation of IgG and IgM antibodies to synthetic cannabinoids and antidepressants in mice in the experiment. It has been established that IgM antibodies play a significant role in the diagnosis of psychotropic substances.