Abstract

Background: Prediabetes is a stage of glucose tolerance between normal glucose tolerance and diabetes and is characterized by impaired fasting glucose (IFG) and impaired glucose tolerance (IGT). The prevalence of diabetes and prediabetes is rapidly rising in India, in both urban and rural sectors. Obesity represents one of the major modifiable risk factors of the disease and waist-to-height ratio (WHtR) accounts as being one of the indicators of obesity and its association with IFG and IGT in nondiabetics needs to be studied. Aims and Objectives: This study aims to assess if a correlation exists between IFG and IGT and W: Ht ratio in a non-diabetic population.
Materials and Methods: A total of 150 subjects, over the age of 20 years from village Hatpiplia, district Dewas, Madhya Pradesh, who were not known cases of diabetes mellitus were evaluated. Anthropometric measurements included waist circumference (in cm) and height (in cm) and WHtR was calculated. Blood samples for fasting blood sugar and 2-h post-glucose blood sugar were taken and analyzed on fully automated analyzer MERCK Microlab 300 LX by enzymatic colorimetric method.
Results: The prevalence of IFG was found to be 18% (95% confidence interval [CI] 12.68– 24.92) and 15.3% (95% CI 10.44–21.96) had IGT based on their 2-h post-glucose loading blood sugar levels. About 74% of the subjects who had IFG and 69% of the subjects with IGT were also found to have impaired WHtR. Moreover, more than 80% of the patients with newly detect diabetes had an impaired WHtR. Conclusion: Prediabetes is a growing concern in rural India and if we aim to control the epidemic of diabetes then focus has to be directed toward the stage of IFG and IGT where awareness and lifestyle intervention programs need to implement at basic levels. There is a strong association between impaired WHtR and prediabetes marking it as a very important prognostic indicator in the occurrence of the disease