Abstract

Background: In Type 2 diabetes (T2D) mellitus, chronic hyperglycemia and hyperinsulinemia with resultant increased advanced glycosylated end products cause the acceleration of the brain aging in its structure and functions. This complication increases the risk of memory and cognitive dysfunctions. Aims and Objectives: This study was aimed to compare the memory and cognitive functions between controlled and uncontrolled T2D mellitus patients.
Materials and Methods: The study is undertaken in the Department of Physiology, Velammal Medical College Hospital, Madurai. 100 known T2D mellitus patients aged between 30 and 50 years of both sexes are included after obtaining informed written consent. Patients with conditions and factors affecting memory and patients with defective hearing and speech are excluded from the study. Recent hemoglobin A1c (HbA1c), fasting blood sugar (FBS), and postprandial blood sugar (PPBS) values are collected from their hospital records. Cognition and memory assessment is done using Mini-Mental State Examination (MMSE) by 30-point questionnaire.
Results: The average MMSE score of uncontrolled diabetes mellitus is less than the average MMSE score of controlled diabetes mellitus patients (HbA1c