Abstract

Background: One of the major problems in treatment patients of hypertension (HTN) is controlling their systolic blood pressure (SBP) and diastolic BP (DBP). Aims and Objectives: This study aims to study the efficacy of cilnidipine and amlodipine used for the treatment of HTN at tertiary health-care center.
Materials and Methods: The present study was undertaken by the Department of Pharmacology in collaboration with the Department of Medicine on newly diagnosed patients of HTN attending medicine outpatient department of Bidar Institute of Medical Sciences, Bidar, for a period of 9 months from May 2018 to January 2019. 100 patients aged 18–60 years of either sex were included in the study. Data were analyzed using the SPSS version 22.0. Quantitative data are presented as means and standard deviation (SD) (mean ± SD).
Results: After 8 weeks of treatment, a gradual decline in SBP from 149.2 ± 12.57 at baseline to 131.04 ± 6.02 and DBP from 94.22 ± 6.76 at baseline to 84.36 ± 1.79 was noted in cilnidipine group. Gradual decline in SBP from 151.56 ± 10.21 at baseline to 132.72 ± 4.91 and DBP from 95.4 ± 5.70 at baseline to 82 ± 2.55 was noted with amlodipine group. Statistical analysis using paired t-test was obtained which is statistically significant, P = 0.00001. Conclusion: It can be concluded that both the drugs significantly reduced BP, but cilnidipine found superior to amlodipine for reducing systolic BP and equally efficacious in reducing DBP.