Abstract
Background: Antimicrobial resistance is a grave global public health concern and has escalated in recent past. Aims and Objectives: This study was conducted to analyze the antimicrobial resistance pattern of commonly isolated microorganisms in a secondary care hospital in Saudi Arabia. Materials and Methods: This cross-sectional observational study was conducted at King Khalid Hospital, Al Majmaah. Antimicrobial resistance pattern of commonly isolated Gram-negative and Gram-positive microorganisms was checked against routinely used antimicrobials. Results: The prevalence rate calculated for methicillin-resistant Staphylococcus aureus was 44.2%. Extended-spectrum beta-lactamase Enterobacteriaceae was 14.70% and vancomycin-resistant enterococci were 8%. Conclusion: There is an increase in proportion of isolates resistant to commonly prescribed antibiotics highlighting the importance of ongoing surveillance and antibiotic stewardship program.