Abstract

Background: Reviewing the previous studies reveals that the balance between stimulators and inhibitors of angiogenesis is of a great deal of importance. Among these factors, it can be pointed to the ANGPT2-like protein and the interferon (IFN)-beta. Since hypoxia is one of the most powerful stimulators of angiogenesis and considering the fact that endurance training creates a hypoxia condition. Aims and Objectives: The purpose of the present study was to investigate the effects of 8 weeks of non- continuous aerobic exercise on levels of angiopoietin2-like proteins and IFN beta (IFNβ) in male rats suffering from coronary artery disease.
Materials and Methods: To this end, 32 months old rats weighting between 200 and 250 g were randomly selected. Afterward, 20 of the rats were made sick and further divided into two 10 member groups of control and experimental. The experimental group received 5 sessions of non-continuous aerobic exercises on animal per week for 8 weeks on an animal treadmill while the control group did not receive any exercises during these 8 weeks. After the period of the experiment, 5 mL of blood was taken from reach rat’s lower inferior vein 72 h after the past exercise after anesthetization by expert animal surgeons. Research data have been analyzed using the ANOVA test and the SPSS v.0.24 Software.
Results: Research findings indicate that after 8 weeks of participation in non-continuous aerobic exercises, a certain statistically significant difference was made between the control and experimental groups in terms of the level of IFNβ. However, no statistically significant difference was recorded for the level of angiopoitein-2 like proteins. Conclusion: In general and with respect to the obtained results it can be stated that 8 weeks of non-continuous aerobic exercises did not result in an increase in the angiopoietin-2 like proteins level while resulting in a statistically significant decrease in the level of IFNβ.