Abstract

Dapsone is widely used for the treatment of leprosy and other immunological and inflammatory dermatological conditions such as dermatitis herpetiformis, vesiculobullous dermatoses, and pustular psoriasis. Dapsone hypersensitivity syndrome (DHS) is a rare reaction associated with fever, skin eruptions, and internal organs involvement. We report a case of DHS who presented with fever, productive cough, dyspnea, skin rashes, and jaundice. Leukocytosis, eosinophilia, and altered liver enzymes were observed in laboratory investigations and patient improved with conservative management.