Abstract

Background: Rhizome of Curcuma longa has many therapeutic implications in traditional Indian medicine. It is used in traditional medicine for flatulence, dyspepsia, and other gastric problems. There is conflicting reports regarding its anti- ulcer and ulcerogenic potential. Aims and Objectives: The study is with the aim of determining the gastoprotective effect of C. longa extract on aspirin-induced gastric ulcer in rats.
Materials and Methods: C. longa rhizomes were collected locally. Preparation of extract was done with 50% ethanol using Soxhlet extraction. Albino rats of Wistar strain were used for the study. Aspirin was purchased from Sigma Labs, Mumbai. Anti-ulcer effect of the extract was studied in rats after inducing mucosal damage by aspirin.
Results: It was found that extract of C. longa exhibited significant protection against aspirin-induced ulcer at dose levels of 250-mg/kg, 500-mg/kg, and 1000 mg/kg body weight. There is a dose-dependent increase in the ulcer protective action of the extract. Conclusion: The present study with extract of C. longa revealed its anti-ulcer activity.