Abstract

Background: Metabolic syndrome (MS) is a constellation of diseases caused by several interconnected cardiometabolic risk factors such as obesity, hypertension, hyperglycemia, and dyslipidemia. Lipid-lipoprotein ratios can be considered as an alternative for identifying individuals with MS. Objectives: The objectives of this study were to compare the lipid profile and lipid-lipoprotein ratios of different groups formed based on the progression of the severity of MS.
Materials and Methods: A total of 195 participants who volunteered with the signs of MS were divided into three groups based on the presence of metabolic abnormalities as Group I (with <3 components of MS - control group), Group II (with any three components of MS group), and Group III (with >3 components of MS - severe MS group).
Results: Results showed that triglycerides (TG), ratio of TG-to-high-density lipoprotein, and total cholesterol (TC)-to-high-density lipoprotein ratio showed significant difference (P < 0.001) between the groups, whereas the results of high-density lipoprotein and low- density lipoprotein-to-high-density lipoprotein ratio were significantly more (P < 0.001) in severe MS in comparison with control and MS. TC showed significant difference (P = 0.004) in MS and severe MS when compared with that of control. Conclusion: Early identification and treatment of individuals with MS is very important to prevent debilitating effects associated with its development.