Abstract

Background: Dipeptidyl peptidase-4 enzyme not only inhibits incretins but also many other substrates and has wide distribution. Inhibition of this enzyme may have many implications, one of which is to improve wound healing. Aims and Objectives: This aim of this study is to evaluate wound healing property of linagliptin, saxagliptin, sitagliptin, and vildagliptin on excised wounds in non-diabetic Wistar albino rats.
Materials and Methods: Some commonly used gliptins, linagliptin, saxagliptin, sitagliptin, and vildagliptin were assessed for pro-wound healing property on excised wound in non-diabetic Wistar albino rats. Wound healing was assessed by measuring the scar area at 4,8,12 & 16 days and the time taken for the complete scar th formation.On the 16 day, rats were sacrificed, wound tissue biopsy was taken for assessing granulation tissue and serum was subjected for tumor necrosis factor-1α, interleukin-6, inducible nitric oxide synthase, hydroxyproline and glucose estimation.
Results: Pro-healing property was not uniform among various tested gliptins, only linagliptin and sitagliptin were found to have improved wound healing potential in rat excised wound. Conclusion: Gliptins show variable effect on wound healing.