Abstract

Background: Chronic alcohol consumption is a known risk factor for liver disease, which represents a major cause of morbidity and mortality worldwide. The present experimental model was evaluated with medicinal plant Boswellia serrata and the results reflectedpotential beneficial and reducing risk factors for liver disease.AimsandObjectives: To determine the hepatoprotective activity of aqueous extract of Boswellia serrata. Chronic ethanol consumption is a major risk factor in determining liver disease and other metabolic syndrome via multiple mechanisms, including the regulation of the lipid metabolism.
Materials and Methods: Male Wistar rats were divided into 6 groups (n = 6/group), and fed with a standard diet, ethanol, and ethanol supplemented with extracts for 6 weeks. The ethanol changes were determined via a serum enzyme profile of the liver. Liver toxicity was assessed in terms such as, serum indirect bilirubin, aspartate aminotransferase, alanine aminotransferase, total proteins, albumin, globulin, albumin: globulin ratio, and liver weight.
Results: Oral administration of 250 and 500 mg/kg of Aqueous extract of Boswellia serrata offered a significant (Po 0.01) dose-dependent protection against ethanol-induced hepatotoxicity.Conclusion: This study revealed that aqueous extract of Boswellia serrata in phytochemical constituents plays an active role against enzymes’ elevation and protection of liver.