E-ISSN 2231-3206 | ISSN 2320-4672

2016, Vol:6,Issue:3

Research Articles
  • Natl J Physiol Pharm Pharmacol.2016; Volume:6(3):178-181 doi : 10.5455/njppp.2016.6.27122015107
  • Cardiac autonomic dysfunction and ECG abnormalities in patients with type 2 diabetes mellitus – a comparative cross sectional study
  • Vijay Prasad C , Darshan Savery M , Vishnu Prasad R

Abstract

Background: Globally, diabetes mellitus has now emerged as a major public health problem, especially in India. Diabetic neuropathy may occur in nearly half of the patients with long-standing diabetes mellitus. In diabetes mellitus, the determinants of cardiac autonomic dysfunction were duration of diabetes, extent of glycemic control, age, and gender. Aims and
Objective: To study the various ECG abnormalities in type 2 diabetes mellitus patients when compared with control subjects.
Materials and Methods: The study was carried out as a hospital-based cross-sectional study among 50 diabetic patients and 50 age- and sex-matched control subjects. Resting ECG was recorded among study and control groups and compared. SPSS, version 20.0, was used for statistical analysis; unpaired t test was used to test the statistical difference in comparison of means, and a p value ofo0.05 was considered statistically significant. Result: The study results showed that certainECGchangessuchasrestingheartrate,RRinterval,PRinterval,QRSaxis,andQTcintervalsignificantlyvariedbetween study and control groups. Abnormal heart rate response to deep breathing and postural hypotension were observed at higher frequencyamongpatientswithdiabetesmellitus.Conclusion:EvaluationofvariouscardiovascularreflexesandECGintype2 diabetic patients may serve as a feasible technique to determine the presence of cardiac dysautonomia.