Abstract
Background: Liver cancer is a deadly disease and devastating public health problem globally. Natural plant products with potent growth inhibition, and apoptosis induction properties are extensively being investigated for their cancer-preventive potential. Allium ascalonicum, being an important part of the diet across various countries, possesses numerous therapeutic effects and health-enhancing properties such as cancer prevention. Aims and Objective: To investigate anticancer activity of dry and fresh A. ascalonicum. Materials and Methods: The organic (ethanol) extracts of dry and fresh shallot bulb (A. ascalonicum)were prepared and tested for in vitro anticancer efï¬cacy on liver cancer cell line HepG2 by MTT (3-(4, 5-dimethylthiazol-2-yl)-2,5- diphenyltetrazoliumbromide)assay.Results:Theresultsshowedthatbothdryandfreshshallotextractshaveanticancerpotential with inhibitory concentration (IC )of50 mg/mL. Conclusion: The plant investigated possesses remarkable anticancer activity. 50 Further studies are essential for the isolation of lead molecules from the plant to treat liver cancer.