Abstract

Background: Fluorosis is an endemic problem in many countries of the world. Aims and Objectives: To see the effect of fluoride on the reproductive system and to see the role, if any, of vitamin D analog paricalcitol on it.MaterialsandMethods: Sixtyrabbitsweredividedintofourequalgroups.GroupIwasfedonstandarddiet,GroupIIvehicle-treated control,GroupIII on sodium fluoride (NaF) 20 mg/kg body weight, and Group IV on NaF + paricalcitol. Result: In Group III (fed on NaF) significant decrease in sperm count (Po 0.001) and motility (Po 0.001) was seen compared with control. With vitamin D analog paricalcitol, there was a significant improvement in the sperm count (Po 0.001) and motility (Po 0.01). All of these significant changes were evident by histopathological evaluation of testicular biopsies. Conclusion: Vitamin D analog paricalcitol treatment showed a significant improvement in reproductive functions.