Abstract

Background: Murraya koenigii, commonly known as karipatta or curry leaf, is analgesic and can be used effectively against inflammation and itching. The various pharmacological activities such as vasodilation, antimicrobial, antidiabetic, antiulcer, analgesic, phagocytic, andantioxidant activitiesofthisplanthave also beenreported.AimsandObjectives:Toevaluatethe anti-inflammatoryandanalgesicactivityofaqueousextractofdriedleavesofM.koenigiiLinn.inmaleWistarrats.Materials andMethods:AdultmaleWistarrats(100–150gbodyweight)wereusedinthisstudy.Aqueousextractof M. koenigiiLinn. was used to evaluate acute anti-inflammatory and analgesic activity by plethysmometer and hot plate method by oral administrationatdosesof100,300,and500mg/kgbodyweightinhealthyalbinorats.Result:Inacutestudies,theaqueous extract showed anti-inflammatory activity by significant reduction in the paw edema volume, in a dose-dependent manner whencomparedwiththecontrolandstandarddrug.Aqueousextractof M. koenigiiLinn.significantlyanddose-dependently reduced the number of acetic acid-induced writhing and significantly increased the latency of paw licking in hot plate method. Statistical analysis was carried out by one-way ANOVA, followed by Turkey’s test. Conclusion: Aqueous extract of M. koenigii Linn. possesses both anti-inflammatory and analgesic activity in a dose-dependent manner.