Abstract

Background: Hypothyroidism is a progressive disorder that presents with diverse degrees of thyroid failure and metabolic consequences. Purine metabolism can be affected by disturbance in thyroid hormones, which leads to alteration in the uric acid levels,leadingtohyperuricemiaandsubsequentlycausinggout.Also,hemodynamicchangesoccurinhypothyroidismthatleadsto reductioninrenalplasmaflowandglomerularfiltrationrate,whichalsocausesincreaseinthelevelsofserumuricacidandserum creatinine.Aimsand
Objective: To determine whetherthyroiddysfunction, subclinical and overt,hasdeleteriouseffects onrenal function.MaterialsandMethods: This was a cross-sectional study that comprised 108 individuals (56 cases and 52 controls; 52 men and 56 women) aged between 20 and 60 years. Case group comprised suspected cases of hypothyroidism. Serum TSH, T4, T3, uric acid, and creatinine were estimated after applying inclusion and exclusion criteria.Result: Uric acid and creatinine levels ± ± ± weresignificantlyelevatedincasegroupascomparedto controlgroup(7.09 0.45and1.52 0.16mg/dLversus4.08 0.25 ± and 0.62 0.05 mg/dL, respectively; po 0.001). There was insignificant correlation between serum uric acid and creatinine levels with hypothyroidism (r = 0.185, p=0.172and r=0.082, p = 0.550). Also, there was no significant correlation between serumuricacidandcreatininelevelswiththeageinhypothyroidism(r=0.143; p=0.292and r= -20.154; p=0.257,respectively). Conclusion: Hypothyroidism causes significant increase in serum uric acid and creatinine levels. Therefore, we would emphasize the importance of the routine evaluation of serum uric acid and creatinine levels in patients with hypothyroidism.