Abstract

Background: Tamarindus indica L is widely used as a traditional medicine. In Indonesia T. indica L is commonly used to treat gastritis, rheumatism, constipation, and fever. Aims and
Objective: The purpose of this study was to examine thehypolipidemiceffectof70%ethanolicextractofT. indicaLfruitfleshandrindandtheirchemicalcompounds.Materials andMethods:Atotalof40Wistarmaleratsweredividedinto8groups.groupIwasnegativecontrol(aquabidest);groupII was positive control (Simvastatin 0.72 mg/gbw); groups III, IV, and V were treated by 70% ethanolic extract of the flesh fruitwithdosesof200,100,and50mg/kgbw,respectively;groupsVI,VII,andVIIIweretreatedby70%ethanolicextractof the rind fruit with doses of 200, 100, and 50 mg/kgbw, respectively. The extract was given for 7 days after the third day. Measurement of plasma total cholesterol and triglyceride were carried out on days 0, 3, and 10. Result: The results show thatthe 70%ethanolic extractof T. indicaLfruitrindandfleshwithdosesof 200,100,and 50mg/kgbw canreduceplasma total cholesterol and triglyceride significantly (Po 0.01). Chemical content of 70% ethanolic extract of T. indica L fruit rind and flesh by thin-layer chromatography examination are alkaloids, flavonoids, terpenoids, and phenolic. Conclusion: The 70% ethanolic extract of T. indica L fruit flesh and rind exert effect for lowering total cholesterol and triglyceride on hyperlipidemia induced by Triton X-100 in Wistar rats.