Abstract

Background: Ganoderma lucidum, commonly referred to as Lingzhi in China, is a fungus that has been widely used through the centuries for the general promotion of health and longevity in Asian countries. Aims and
Objective: To determine the effects of subchronicexposureofPSPG.lucidumonrenalfunctionandrenalhistopathologyfeatureinRattusnovergicusWistarstrain.Materials andMethods: A total of 80 male and female Wistar rats, aged 2–3 months with a body weight of 200–300 g, were divided into four treatment groups: dose group 0 (control group), group PSP G. lucidum dose of 300, 600, and 1200 mg/kg for 90 days. Parameters measured were urea and creatinine levels and renal histopathology feature. Result: From the research, the highest urea levels were foundinthegroupinwhichfemale Wistarrats weretreatedwithPSP doseof 300mg/kg/daywithanaverageconcentrationofurea of33.2mg/dL,whereascreatininelevelswerefoundtobeequallyhighontreatmentwithPSPdoseof1200,600,and300mg/kg/day with an average concentration of urea of 0.3 mg/dL. On histopathological examination, no morphological abnormalities were found. The results of one-way analysis of variance test showed no significant difference at all PSP G. lucidum doses. Conclusion: It is concluded that giving PSP G. lucidum in three variant doses does not cause dysfunction and histological damage to the renal function.