Abstract
Background: The physiologic mechanisms whereby the human endometrium maintains hemostasis during endovascular trophoblast invasion, yet permits menstrual hemorrhage, are unknown. Aims and Objective: To ï¬nd out whether hemostatic responses alter during various phases of normal menstruation. Materials and Methods: In this study height, weight, body mass index, pulse, and blood pressure were measured in 60 female volunteers having normal, regular menstrual cycle. Bleeding and clotting time were measured during three phases of single menstrual cycle: menstrual, follicular, and luteal. One-way analysis of variance test with Bonferroni correction was used to ï¬nd out statistical signiï¬cance.Results:Thisstudyshowsmeanbleedingtimeatfollicularphasewassigniï¬cantly(Po0.05)lessascompared to that at menstrual and luteal phases. Mean clotting time at follicular phase was comparatively less than that at menstrual andlutealphases,butthedifferencewasnotsigniï¬cant(P40.05).Conclusion:Ourobservationsindicatethatprimaryand secondary hemostatic mechanism activities are at their high in the follicular phase than in the luteal and menstrual phases.