Abstract

Background: The relationship between uric acid and microalbuminuria in healthy adults without other cardiovascular risk factors may help to clarify the role of uric acid in cardiovascular disease.
Objective: To study and compare the association of serum uric acid levels with microalbuminuria in normotensive and pre-hypertensive subjects without a history of cardiovascular disease or renal dysfunction.
Materials and Methods: 350 subjects were included in study. All the routine investigations along with serum uric acid and urinary albumin were conducted. Microalbuminuria was detected by immunoprecipitation in a random urine sample. Serum uric acid level was estimated by Spectrophotometry.
Results: The overall prevalence of prehypertension was 38.06% (Males, 39.10% and females, 35.56%). The total prevalence of microalbuminuria was 11.61% (9.9% of normotensives and 14.4% of pre-hypertensives). Hyperuricemia was seen in 10.32% of the total study population. Among normotensives, 9% of males and 8.6% of females and in pre-hypertensive subjects, 14% of males & 9.4% of females had hyperuricemia. Among the prehypertensives, those with microalbuminuria had a significantly higher (p