Abstract

Background: Most of the currently available therapies for peptic ulcer disease have their own limitations and an ideal therapeutic agent is not yet available in the market.Hence,we decided to explore the cytoprotective potential of Indian Medicinal Plants namely Phyllanthus emblica and Asparagus racemosus along with ranitidine as a positive control in various animal models. Aims &
Objective: To evaluate the cytoprotective effect of the extracts of Phyllanthus emblica (PE) and Asparagus racemosus (AR) in preventing gastric erosions, ulcerations and inflammation induced in rats.
Materials and Methods: Cold immobilization stress, ethanol (99.9%), aspirin were the experimental models selected for inducing gastric erosions and ulcerations. Ulcer index , erosions, oedema, congestion and inflammation were the parameters studied for assessing gastric damage whereas carrageenininduced rat paw oedema model was used to induce inflammation. Ranitidine was used as a positive control.
Results: The two drugs chosen for the study namely Phyllanthus emblica and Asparagus racemosus prevented gastric damage significantly in the ethanol group (p