Abstract

Background: Diabetes mellitus is a serious disorder of carbohydrate, protein, and fat metabolism researchers on alternative medications in the management of diabetes with low costly and little or no side effect over long-term use still continue. Aim and
Objective: This study evaluated how Momordica charantia (MC) improved biochemical indices in alloxan-induced diabetic rats.
Materials and Methods: Twenty-five male rats whose weights were between 150 and 200 g used for this study were divided into five groups with five rats per group. Group A received water, Groups B, C, D, and E were all diabetic but received water, aqueous leaf extract of MC, aqueous leaf extract of MC, and anti-diabetic drug and anti-diabetic drug only, respectively. Treatments were carried out for 21 days; from the blood sample, liver enzymes, lipid profile, blood electrolytes, and glucose were determined using standard methods.
Results: Observation from results showed that blood glucose, liver enzymes, lipid profile, and blood electrolytes in diabetic groups treated with MC when compared with diabetic group reduced significantly (P < 0.05). Conclusion: The management of diabetes induced with alloxan in rats treated with aqueous leaf extract of MC reduced the chance of chronic renal failure, hyperlipidemia, liver disease, and excessive gain in body weight.