Abstract

Background: Adjuvant play very important role in regional anesthesia and search for better adjuvant is still going on. Objectives: The objectives of this study are to find equipotent doses and to compare the efficacy of two α agonists 2 clonidine and dexmedetomidine as an adjuvant in supraclavicular block.
Materials and Methods: A total of 90 patients of the American Society of Anaesthesiologists 1 and 11 of age 20-50 years undergoing elective upper limb surgeries under supraclavicular block divided into three groups: Group N: Received injection bupivacaine 0.5% 15 ml + injection. Lignocaine with adrenaline 2% 15 ml + normal saline 0.5 ml. Group D: 1 µg/kg dexmedetomidine. Group C: 1.5 µg/kg clonidine as studied drug in place of normal saline. Onset, duration of sensory and motor block, duration of analgesia, visual analog scale (VAS) score, hemodynamics, sedation, and other side-effects noted down.
Results: Onset of sensory and motor block in Group D (8.13 ± 2.52 and 12.13 ± 2.90), Group C (7.97 ± 2.58 and 12.47 ± 2.89), and Group N (12.43 ± 2.57 and 17.97 ± 3.06) groups, respectively. Duration of sensory and motor block was 528.2 ± 105.27 and 464.17 ± 93.15 in Group D, 544.97 ± 113.51 and 476.57 ± 105.41 in Group C, and 292 ± 77.4 and 257 ± 75.63 in Group N, respectively. Duration of analgesia was 644.93 ± 118.45 in Group D and 646.93 ± 112.18 in Group C and 352.6 ± 84.39 in Group N. Both studied groups were comparable to each other in above parameters and are significantly better than Group N. VAS score in the post-operative period at 360 min was higher in Group N (5.12 ± 0.68) when compared to Group C (4.5 ± 0.73) and Group D (2.07 ± 0.94), respectively. Conclusion: Dexmedetomidine and clonidine as an adjuvant to supraclavicular block were found equipotent in the studied doses. However, post-operative VAS was found low in dexmedetomidine group.