Abstract
                 Background: Orthopedic wound infections are one of the most important causes of morbidity and are difficult to treat.  Changes in pathogenic microbial flora and the emergence of bacterial resistance are another problem in the management  of orthopedic infections. Objectives: In this regard, an attempt was made to know the bacteriological profile and their  antibiotic susceptibility pattern in our hospital. Materials and Methods: This study was conducted in the Department of  Microbiology, Narayana Medical College & Hospital, Nellore, over a period of 1-year from June 2015 to May 2016. A total  of 100 pus samples were collected and processed during the mentioned period. Results: Out of the samples processed,  68 (68%) of specimens showed culture positivity. Pseudomonas aeruginosa 18 (26.4%) was the predominant isolate  followed by Staphylococcus aureus 17 (25%). All Gram-positive cocci were susceptible to vancomycin and linezolid.  Pseudomonas isolates were susceptible to polymyxin B, piperacillin-tazobactam, and meropenem. Conclusion: Microbial  analysis and their antibiogram of clinical samples are mandatory since it is deep seated infections with more pathogenic  bacteria for optimal management of orthopedic infections.