Abstract

Background: Hepatic steatosis in Non-Alcoholics may range from a ‘benign’ indolent deposition of fat [known as non- alcoholic fatty liver diseases (NAFLD)] to severe lipotoxicity-induced steatohepatitis with neuroinflammation [known as non-alcoholic stea - tohepatitis (NASH)]. NASH is an overlooked complication of Type-2 diabetes mellitus (T2DM) that if missed may carry serious long-term consequences. Objectives: To determine the Predictors of Non-alcoholic fatty liver disease and Non-alcoholic steatohepatitis in patients with Type-2 Diabetes Mellitus.
Materials and Methods: Fatty liver Disease by Ultrasonography & various other relevant factors (clinical and biochemical) were measured in all study subjects. These parameters were compared among two study groups i.e. (NAFLD and normal Liver). The statistical analyses were done using Statistical Analytic system (SAS), Chi-square test & Fisher Exact test were applied.
Results: Incidence of Non-alcoholic fatty liver disease in our study is around 62 (59.7%) of which 37 (55%) are males and 25 (45%) are females. The incidence of Non-alcoholic steatohepatitis in this study is around 22 (25.5%) of which 15 are males and 7 are females. BMI and WC values are significantly higher in the fatty liver group than normal group. ( p<0.011 and p<0.001 respectively). Conclusion: The prevalence of NAFLD is high amongst T2DM patients and, considering the increased liver mortality among these patients, NAFLD should be actively sought out and treated in patients with diabetes. Insulin resistance does not seem to be correlated with the presence of NAFLD among T2DM patients.