Abstract

Background: Metabolic syndrome (MetS) and decreased adiponectin level have been reported to be clinically associ- ated with type 2 diabetes mellitus and coronary artery disease (CAD). Serum level of adiponectin has been shown to be reduced in several disease states like obesity and diabetes. The clinical relationship between serum adiponectin level and MetS and its association with insulin resistance has been investigated.
Objective: The present study was designed to compare the fasting adiponectin level with the insulin and insulin resist- ance between metabolic syndrome patients and healthy subjects.
Materials and Methods: The present study included 140 metabolic syndrome cases (81 men and 59 women) and 100 healthy controls. Metabolic syndrome cases were diagnosed by NCEP ATP III criteria. Serum adiponectin, leptin , insulin, glucose and lipid profile measured and insulin resistance, leptin and adiponectin ratio and BMI were calculated. Result: All the parameters were significantly ( p < 0.0001) high in metabolic cases excepts HDL-C and adiponectin which were significantly ( p < 0.0001) low. In both men and women, adiponectin levels are negatively correlated with triglycerides, VLDL, insulin, LAR, and leptin while positively with HDL-C. Pearson’s correlation coefficient ( r) is also performed between LAR level and metabolic factors, the strong positive relation of LAR is obtained with TG, VLDL, and leptin while strong negative relation with adiponectin (p < 0.0001). Conclusion: The present study concluded that decreased adiponectin level observed in metabolic cases, which was low in men compare to women. The finding indicate that adiponectin may have a wide role in metabolism of lipoprotein. It may act as an anti atherosclerotic factor through improving insulin resistance and lipid profile.