Abstract

Background: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of reproductive age group. The QTc interval duration, which is related to cardiac arrhythmia, sudden death, and a sign of cardiac autonomic neuropathy, has not been investigated thoroughly in PCOS population. Aim and Objectives: The aim of the present study was to investigate the potential alterations in electrocardiographic (ECG)–QT parameters in lean and ideal weight young Indian patients with PCOS. Material and Methods: Briefly, 24 classical PCOS diagnosed by Rotterdam 2003 Diagnostic criteria and were lean or ideal weight as per WHO criteria and 24 BMI matched, age matched normally menstruating women served as study participants. All of them underwent assessments clinically and by appropriate laboratory tests. Metabolic pattern was assessed and ECG analysis was performed for evaluating QT interval, minimum and maximum QT interval (QTmax and QTmin, respectively), QT dispersion (QTd), minimum and maximum QT interval corrected for heart rate (QTcmin and QTcmax, respectively), corrected QT dispersion (QTcd), and QT/QTc ratio.
Results: QT (388 ± 35 vs 431 ± 53 ms, P-value < 0.01); QTmax (427 ± 46 vs 467 ± 64ms, P-value < 0.05); and QTmin (355 ± 4 vs 400 ± 48 ms, P-value <0.001) were significantly different. QTd (65 ± 32 vs 67 ± 38 ms, P-value = 0.834); QTc (454 ± 34 vs 473 ± 56 ms, P-value = 0.103), QTc max (492 ± 37 vs 512 ± 69 ms, P-value 0.216), QTc min (417 ± 37 vs 439 ± 50 ms, P-value = 0.072), and QTcd (76 ± 34 vs 74 ± 44 ms, P-value = 0.808) were not significantly different between PCOS and healthy women. Conclusion: Our data demonstrate no significant difference in QTc parameters in PCOS compared to healthy controls. This shows PCOS may not be under increased risk of developing cardiac arrhythmias compared to control population.