Abstract

Background: Hepatic disorders are prevalent in all ages. They are challenging to both pathologist as well as clinician in view of the ill-understood etiopathogenesis. Histological assessment of the liver should be performed and thus, liver biopsy is a cornerstone in the evaluation and management of patient with chronic liver disease.
Objective: To study histological spectrum in patient of chronic liver diseases, correlate clinical and biochemical features with morphology on liver biopsy, and to evaluate the role of liver biopsy in the diagnosis and management of chronic liver disease.
Materials and Methods: This study is based on liver biopsies obtained from 62 patients with suspicion of chronic liver disease based on clinical features and findings on other investigations. Relevant biochemical and other investigations were done before liver biopsy was resorted. The size of the intact liver biopsy obtained are ranged from 1.5 to 2.5 cm, though fragmented biopsy was also obtained in certain cases and was subjected to routine H and E staining and special stains in some cases were performed. Result: Out of 62 biopsies performed, fatty liver due to non- alcoholic steatohepatitis (NASH) was seen in 27% of cases followed by alcoholic cirrhosis in 19% of cases while least case was found due to hepatitis C in only 03% cases. Males were affected more. Conclusion: Liver biopsy study is the gold standard for diagnosis of chronic liver diseases.