Abstract

Background: Improvement in glycemic control, particularly early in the treatment, is associated with reductions in the incidence of microvascular complications, including chronic kidney disease (CKD).
Objective: To study the effect of glycemic control on diabetic nephropathy (DN) in patients with type 2 diabetes.
Materials and Methods: We investigated progression of DN by measuring glycosylated hemoglobin (HbA1c), serum creatinine, and glomerular filtration rate (GFR) level in 70 (37 men and 33 women) patients with type 2 diabetes mellitus (DM) on antihypertensive treatment. Result: The survey was done for 6 months during which 40 patients with DM (group 1) with serum creatinine <1.2 mg/dL were compared with 30 patients with DM (group 2) with serum creatinine ≥1.2 mg/dL who had mean HbA1c of 9.0%. In group 2, the mean level of serum creatinine (1.71 ± 0.46 mg/dL) was significantly higher and the mean GFR (54.57 ± 35.26 mL/min) was significantly lower than group 1 ( P < 0.05). Conclusion: Uncontrolled glycemic control leads to progression of DN with an earlier decline in GFR in patients with type 2 diabetes.