Abstract

Background: Hemoglobinopathies are common genetic disorders and represent a significant load of anemic patients coming to a hospital with various complaints.
Objective: To assess the different types of hemoglobinopathies prevalent in Odisha in relation to hematological profile and district-wise distribution.
Materials and Methods: This study was done on all the patients who had undergone high performance liquid chroma- tography (HPLC) study in Hi-Tech Medical College and Hospital, Bhubaneswar, Odisha, India, from 2010 to March 2015 whose complete history and data required for this study were available. Bio-Rad dual cation exchange high performance liquid chromatography (CE-HPLC) machine was used. Result: Although it was not a screening study, of the 331 cases, 105 were found to be normal. Along with SCD and beta-thalassemia (β-thalassemia), hemoglobin E (HbE), and hemoglobin E-beta thalassemia (HbE/β-thalassemia) cases were found in significant numbers even though this region is not known for its endemicity of HbE hemoglobinopathies. Four cases of HbD-Punjab carriers were also encountered. Conclusion: This study revealed that HbS is the most common abnormal hemoglobin in Odisha, followed closely by β-thalassemia. As in West Bengal, Odisha is also found to be endemic for HbE.