Abstract
Lipomas of the gastrointestinal tract are a rare condition, occurring during the fifth to seventh decades of life, found mainly in women. They are small and asymptomatic lesions and are usually incidentally detected. We evaluated a case of 42-year-old man presenting with an episode of melena and found to have a large duodenal mass on endoscopy, requiring surgical excision. Histopathological diagnosis revealed submucosal lipoma.