Abstract

ABSTRACT Background: Oral cancers are a major health problem in developing country. They usually progress from premalignant conditions of oral cavity. Early diagnosis of these premalignant lesions by histopathology with help of immunohistochemistry can prevent morbidity and many other complications. Aims & Objectives: To investigate the expression of p53 protein and Ki67 antigen in normal, oral premalignant and oral malignant lesions and to find correlation of the expression of this antigen in various premalignant and malignant oral lesions.
Materials and Methods: This study comprises of 39 cases of oral lesions (premalignant and malignant). After processing of representative tissue block, H&E and IHC stain with Ki-67 and p53 immunomarkers were carried out.
Results: Total 39 cases of premalignant and malignant oral lesions were reported in our study. Strong association was found in expression of both p53 and Ki-67 immunomarkers in premalignant and malignant oral lesions in compared to normal mucosa in our study. Conclusion: Increased expression of p53 and Ki-67 immunostain was significantly correlated with progression of oral epithelium from normal to neoplasia and increased expression of these antigens suggest that they may be useful indicator of malignant transformation in dysplastic lesions.