Abstract

ABSTRACT Background: Diabetes is rising globally, particularly in India. India is the second largest country in terms of diabetic population. Majority of Diabetic patients also do suffer from dyslipidaemia. Aims &
Objective: This is an observational study done to establish the relationship between glycosylated Hb level and lipid profile in Indian diabetic population.
Materials and Methods: This is an observational study. 50 diabetic patients were studied between the period of 1990- 2000 between February to November. 16 patients were (32%) females and 34 (68%) were males. They were from 25-72 years of age.
Results: 17 (34%) patients were >60 years of age, 16 (32%) were between 50-60 years of age, 9(18%) were between 40-50 years of age, 6(12%) patient were between 30-40 years of age where only 2 (4%) patient were between 20-30 years of age. Out of the 50, 39 (78%) patients were on oral hypoglycemic drugs, 7 (14%) patients were on insulin and 4 (8%) patients were on insulin and oral hypoglycemic agents. 34 (68%) patients were regularly taking drugs whereas 16 (32%) patients were on irregular treatment. Positive family history of diabetes was found in 7 (14%) and hypertension in 11 (22%) of the diabetic patients and 36 (72%) patients had negative family history. Laboratory results showed a mean FBS of 174mg/dL and PPBS of 264mg/dL. More than two thirds [33 (66%)] of the participants had HbA1c >10% and the rest 17 (34%) had HbA1c <10%. Statistically significant change was observed in serum triglycerides and in serum LDL in patients with higher HbA1c (>10% vs. <10%) whereas changes in other parameters and ratio were statistically insignificant. Conclusion: The current study endorses the positive correlation between uncontrolled diabetes and high serum triglycerides and LDL-C level.