Abstract

ABSTRACT A 35 year old female presented with pain abdomen, massive hematemesis and signs of portal hypertension. Death occurred despite of all efforts to manage shock & hematemesis by endoscopic sclerotherapy. Clinical autopsy revealed gangrene of small intestine with mesenteric vein thrombosis; oesophageal varices; hepatoportal sclerosis (HPS) of liver with regenerative nodules and chronic venous congestion of spleen. Histopathology of liver is essential for diagnosis of HPS & to rule out other disease process. Gangrene intestine in HPS is a rare presentation.